Comprehensive Review of Transarterial Chemoembolization Plus Systemic Therapy in Advanced Hepatocellular Carcinoma

Arif Akyildiz; Betul Gok Yavuz; Rashad Ismayilov; Muge Buyukaksoy; Sena Sozen; Joe Ramzi Eid; Rony Avritscher; Lee Sunyoung; Suayib Yalcin; Ahmed O. Kaseb

doi:10.1007/s12029-025-01306-9

Comprehensive Review of Transarterial Chemoembolization Plus Systemic Therapy in Advanced Hepatocellular Carcinoma

Arif Akyildiz
, Betul Gok Yavuz
, Rashad Ismayilov
, Muge Buyukaksoy
, Sena Sozen
, Joe Ramzi Eid
, Rony Avritscher
, Lee Sunyoung
, Suayib Yalcin
, Ahmed O. Kaseb

Division of Internal Medicine (Medicine)

Hacettepe University
University of Missouri
Baskent University
Ankara Bilkent City Hospital
University of Texas MD Anderson Cancer Center

Research output: Contribution to journal › Review article › peer-review

2 Citations (Scopus)

Abstract

Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common cancer worldwide. For patients with unresectable, localized, intermediate-stage HCC, the standard treatment is transarterial chemoembolization (TACE). Methods: Given the recent advances in systemic treatments for HCC with immunotherapy and targeted therapies, several studies have explored the potential benefits of combining TACE with systemic therapy, owing to the possible synergistic effects. This review analyzes recent clinical studies of patients with unresectable HCC who received TACE in combination with different classes of systemic therapies. Conclusion: Collectively, these studies suggest that combining TACE with systemic therapy may enhance treatment response and improve survival outcomes.

Original language	English
Article number	194
Pages (from-to)	194
Number of pages	18
Journal	Journal of Gastrointestinal Cancer
Volume	56
Issue number	1
DOIs	https://doi.org/10.1007/s12029-025-01306-9
Publication status	Published - Dec 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hepatocellular carcinoma
ICI
TACE
TKI
Transarterial chemoembolization

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10.1007/s12029-025-01306-9

Cite this

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title = "Comprehensive Review of Transarterial Chemoembolization Plus Systemic Therapy in Advanced Hepatocellular Carcinoma",

abstract = "Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common cancer worldwide. For patients with unresectable, localized, intermediate-stage HCC, the standard treatment is transarterial chemoembolization (TACE). Methods: Given the recent advances in systemic treatments for HCC with immunotherapy and targeted therapies, several studies have explored the potential benefits of combining TACE with systemic therapy, owing to the possible synergistic effects. This review analyzes recent clinical studies of patients with unresectable HCC who received TACE in combination with different classes of systemic therapies. Conclusion: Collectively, these studies suggest that combining TACE with systemic therapy may enhance treatment response and improve survival outcomes.",

keywords = "Hepatocellular carcinoma, ICI, TACE, TKI, Transarterial chemoembolization",

author = "Arif Akyildiz and Yavuz, \{Betul Gok\} and Rashad Ismayilov and Muge Buyukaksoy and Sena Sozen and Eid, \{Joe Ramzi\} and Rony Avritscher and Lee Sunyoung and Suayib Yalcin and Kaseb, \{Ahmed O.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.",

year = "2025",

month = dec,

doi = "10.1007/s12029-025-01306-9",

language = "English",

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AU - Akyildiz, Arif

AU - Yavuz, Betul Gok

AU - Ismayilov, Rashad

AU - Buyukaksoy, Muge

AU - Sozen, Sena

AU - Eid, Joe Ramzi

AU - Avritscher, Rony

AU - Sunyoung, Lee

AU - Yalcin, Suayib

AU - Kaseb, Ahmed O.

N1 - Publisher Copyright: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2025.

PY - 2025/12

Y1 - 2025/12

N2 - Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common cancer worldwide. For patients with unresectable, localized, intermediate-stage HCC, the standard treatment is transarterial chemoembolization (TACE). Methods: Given the recent advances in systemic treatments for HCC with immunotherapy and targeted therapies, several studies have explored the potential benefits of combining TACE with systemic therapy, owing to the possible synergistic effects. This review analyzes recent clinical studies of patients with unresectable HCC who received TACE in combination with different classes of systemic therapies. Conclusion: Collectively, these studies suggest that combining TACE with systemic therapy may enhance treatment response and improve survival outcomes.

AB - Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fifth most common cancer worldwide. For patients with unresectable, localized, intermediate-stage HCC, the standard treatment is transarterial chemoembolization (TACE). Methods: Given the recent advances in systemic treatments for HCC with immunotherapy and targeted therapies, several studies have explored the potential benefits of combining TACE with systemic therapy, owing to the possible synergistic effects. This review analyzes recent clinical studies of patients with unresectable HCC who received TACE in combination with different classes of systemic therapies. Conclusion: Collectively, these studies suggest that combining TACE with systemic therapy may enhance treatment response and improve survival outcomes.

KW - Hepatocellular carcinoma

KW - ICI

KW - TACE

KW - TKI

KW - Transarterial chemoembolization

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DO - 10.1007/s12029-025-01306-9

M3 - Review article

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AN - SCOPUS:105017417035

SN - 1941-6628

VL - 56

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JO - Journal of Gastrointestinal Cancer

JF - Journal of Gastrointestinal Cancer

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ER -

Comprehensive Review of Transarterial Chemoembolization Plus Systemic Therapy in Advanced Hepatocellular Carcinoma

Abstract

UN SDGs

Keywords

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