Comparison of autofluorescence and optical coherence tomography findings in acute and chronic central serous chorioretinopathy

AIM To discuss and compare the fundus autofluorescence (FAF) and optical coherence tomography (OCT) in acute or chronic central serous chorioretinopathy (CSCR). METHODS Medical records of l oo cases of CSCR were reviewed. Acute and chronic cases were evaluated according to the duration of decreased visual acuity, serous retinal detachment (RD) and focal leakage on fluorescein angiography (FA). Chi-square test was used for statistical analysis. RESULTS Forty cases had acute and 60 cases had chronic CSCR. FAF showed focal hy po-Autofluorescence in 34 (85%) and iso-Autofluorescence in 6 (15%) of acute cases and hy po-Autofluorescence in 5 1 (85%), hy per-Autofluorescence in 6 (1 0%) and iso-Autofluorescence in 3 (5 96) of chronic cases. OCT showed serous RD with distinct borders correlated with FAF findings (hy po-Autofluorescence) in all acute CSCR cases. In chronic CSCR group, OCT showed serous RD with indistinct borders correlated with FAF findings. The differences between the OCT and FAF findings of the two groups were significant (P=o.ooo). CONCLUSION OCT and FAF findings can support the clinical observations in differential diagnosis of acute and chronic CSCR and help clinicians to evaluate retinal pigment epithelium, outer segments of photoreceptors and the components of serous RD.