Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: A rare case

Meriç Kaymak-Cihan; Ajlan Tükün; Barış Kuşkonmaz; Bilgin Arıbaş; Işınsu Kuzu; Serpil Dizbay-Sak; Nazire Terzi; Ayşenur Paç; Nural Kiper; Macit Arıyürek; Lale Olcay

Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: A rare case

Meriç Kaymak-Cihan
, Ajlan Tükün
, Barış Kuşkonmaz
, Bilgin Arıbaş
, Işınsu Kuzu
, Serpil Dizbay-Sak
, Nazire Terzi
, Ayşenur Paç
, Nural Kiper
, Macit Arıyürek
, Lale Olcay

Ankara Oncology Education and Research Hospital
Ankara University
Yüksek İhtisas Training and Research Hospital
Hacettepe University

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 109/L, 3.4% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of “chronic eosinophilic leukemia, not otherwise specified” (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.

Original language	English
Pages (from-to)	444-451
Number of pages	8
Journal	Turkish Journal of Pediatrics
Volume	56
Issue number	4
Publication status	Published - 2014

Keywords

CEL-NOS
Hypereosinophilia
Monosomy 8

Cite this

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title = "Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: A rare case",

abstract = "A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 109/L, 3.4\% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of {\textquotedblleft}chronic eosinophilic leukemia, not otherwise specified{\textquotedblright} (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.",

keywords = "CEL-NOS, Hypereosinophilia, Monosomy 8",

author = "Meri{\c c} Kaymak-Cihan and Ajlan T{\"u}k{\"u}n and Barı{\c s} Ku{\c s}konmaz and Bilgin Arıba{\c s} and I{\c s}ınsu Kuzu and Serpil Dizbay-Sak and Nazire Terzi and Ay{\c s}enur Pa{\c c} and Nural Kiper and Macit Arıy{\"u}rek and Lale Olcay",

year = "2014",

language = "English",

volume = "56",

pages = "444--451",

journal = "Turkish Journal of Pediatrics",

issn = "0041-4301",

publisher = "Turkish National Pediatric Society",

number = "4",

}

TY - JOUR

T1 - Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl

T2 - A rare case

AU - Kaymak-Cihan, Meriç

AU - Tükün, Ajlan

AU - Kuşkonmaz, Barış

AU - Arıbaş, Bilgin

AU - Kuzu, Işınsu

AU - Dizbay-Sak, Serpil

AU - Terzi, Nazire

AU - Paç, Ayşenur

AU - Kiper, Nural

AU - Arıyürek, Macit

AU - Olcay, Lale

PY - 2014

Y1 - 2014

N2 - A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 109/L, 3.4% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of “chronic eosinophilic leukemia, not otherwise specified” (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.

AB - A 5-year-old girl was admitted to our hospital due to fatigue and fever lasting for six months. She had systolic murmur in the mesocardiac and apex regions and hepatosplenomegaly. Laboratory evaluation revealed leukocyte and eosinophil counts of 176 and 144.32 x 109/L, 3.4% blasts in bone marrow and monosomy 8. She developed pulmonary, cardiac, nervous system, ocular and bone involvement. Upon diagnosis of “chronic eosinophilic leukemia, not otherwise specified” (WHO 2008 classification), she received methylprednisolone, vincristine, cytarabine and 6-thioguanine. After hematopoietic stem cell transplantation from a full-matched sibling was performed, the patient expired due to graft failure and septicemia.

KW - CEL-NOS

KW - Hypereosinophilia

KW - Monosomy 8

UR - https://www.scopus.com/pages/publications/84930353284

M3 - Article

C2 - 25818969

AN - SCOPUS:84930353284

SN - 0041-4301

VL - 56

SP - 444

EP - 451

JO - Turkish Journal of Pediatrics

JF - Turkish Journal of Pediatrics

IS - 4

ER -

Chronic eosinophilic leukemia with monosomy 8 in a five-year-old girl: A rare case

Abstract

Keywords

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