Aptamer Moieties in Biochemical Applications

Michael J. Donovan; Ling Meng; Basri Gulbakan; Yan Chen; Parag Parekh; Kwame Sefah; Weihong Tan

doi:10.1002/9780470661345.smc180

Aptamer Moieties in Biochemical Applications

Michael J. Donovan
, Ling Meng
, Basri Gulbakan
, Yan Chen
, Parag Parekh
, Kwame Sefah
, Weihong Tan

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance imaging. Aptamers for these purposes are generated from a process known as SELEX (systematic evolution of ligands by exponential enrichment), or, more precisely when biological cells are used, cell-based SELEX. Aptamers provide a highly target-specific means of transporting drugs to cancer cells. Improved imaging is also possible when aptamers are coupled with micelles, nanomaterials, or hydrogels. These aptamer conjugates show great ability as molecular probes in a variety of applications.

Original language	English
Title of host publication	Supramolecular Chemistry
Publisher	wiley
Pages	1-8
Number of pages	8
ISBN (Electronic)	9780470661345
ISBN (Print)	9780470746400
DOIs	https://doi.org/10.1002/9780470661345.smc180
Publication status	Published - 1 Jan 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

aptamers
cancer cells
conjugation
drug development
molecular conjugate

Access to Document

10.1002/9780470661345.smc180

Cite this

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abstract = "Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance imaging. Aptamers for these purposes are generated from a process known as SELEX (systematic evolution of ligands by exponential enrichment), or, more precisely when biological cells are used, cell-based SELEX. Aptamers provide a highly target-specific means of transporting drugs to cancer cells. Improved imaging is also possible when aptamers are coupled with micelles, nanomaterials, or hydrogels. These aptamer conjugates show great ability as molecular probes in a variety of applications.",

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doi = "10.1002/9780470661345.smc180",

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AU - Donovan, Michael J.

AU - Meng, Ling

AU - Gulbakan, Basri

AU - Chen, Yan

AU - Parekh, Parag

AU - Sefah, Kwame

AU - Tan, Weihong

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance imaging. Aptamers for these purposes are generated from a process known as SELEX (systematic evolution of ligands by exponential enrichment), or, more precisely when biological cells are used, cell-based SELEX. Aptamers provide a highly target-specific means of transporting drugs to cancer cells. Improved imaging is also possible when aptamers are coupled with micelles, nanomaterials, or hydrogels. These aptamer conjugates show great ability as molecular probes in a variety of applications.

AB - Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance imaging. Aptamers for these purposes are generated from a process known as SELEX (systematic evolution of ligands by exponential enrichment), or, more precisely when biological cells are used, cell-based SELEX. Aptamers provide a highly target-specific means of transporting drugs to cancer cells. Improved imaging is also possible when aptamers are coupled with micelles, nanomaterials, or hydrogels. These aptamer conjugates show great ability as molecular probes in a variety of applications.

KW - aptamers

KW - cancer cells

KW - conjugation

KW - drug development

KW - molecular conjugate

UR - https://www.scopus.com/pages/publications/105025838390

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M3 - Chapter

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SN - 9780470746400

SP - 1

EP - 8

BT - Supramolecular Chemistry

PB - wiley

ER -

Aptamer Moieties in Biochemical Applications

Abstract

UN SDGs

Keywords

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