Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling

Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications.Results: APCA (+) and APCA (-) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (-) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (-) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2.Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.