Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery

O. Yildiz; M. Tuncer

doi:10.1097/00005344-199503000-00025

Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery

O. Yildiz
, M. Tuncer

Hacettepe University

Gülhane Military Medical Academy

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT₁-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC₁₀-EC₂₀) of prostaglandin F_2α, (PGF_2α), angiotensin II (AII), histamine. norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT₁like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.

Original language	English
Pages (from-to)	508-510
Number of pages	3
Journal	Journal of Cardiovascular Pharmacology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1097/00005344-199503000-00025
Publication status	Published - Mar 1995

Keywords

Amplification
Precontraction
Rabbit iliac artery
Sumatriptan
Vascular 5-HT-like receptors

Access to Document

10.1097/00005344-199503000-00025

Cite this

@article{6227cceca83941c7a27f1753dc7a66c2,

title = "Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery",

abstract = "Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2α, (PGF2α), angiotensin II (AII), histamine. norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.",

keywords = "Amplification, Precontraction, Rabbit iliac artery, Sumatriptan, Vascular 5-HT-like receptors",

author = "O. Yildiz and M. Tuncer",

year = "1995",

month = mar,

doi = "10.1097/00005344-199503000-00025",

language = "English",

volume = "25",

pages = "508--510",

journal = "Journal of Cardiovascular Pharmacology",

issn = "0160-2446",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery

AU - Yildiz, O.

AU - Tuncer, M.

PY - 1995/3

Y1 - 1995/3

N2 - Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2α, (PGF2α), angiotensin II (AII), histamine. norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.

AB - Rabbit iliac arteries (IA) were almost unresponsive to the serotonin (5-HT1-like) receptor agonist sumatriptan under control conditions, whereas this agent elicited concentration-dependent contractions in IA rings given a moderate tone by threshold concentrations (EC10-EC20) of prostaglandin F2α, (PGF2α), angiotensin II (AII), histamine. norepinephrine (NE), phenylephrine (PE), or potassium chloride. These results suggest that 5-HT1like receptors are uncovered not only by histamine or thromboxane/prostaglandin receptor agonists, as shown in rabbit renal and femoral arteries, but also by various agonists in rabbit IA as shown in this study.

KW - Amplification

KW - Precontraction

KW - Rabbit iliac artery

KW - Sumatriptan

KW - Vascular 5-HT-like receptors

UR - https://www.scopus.com/pages/publications/0028968550

U2 - 10.1097/00005344-199503000-00025

DO - 10.1097/00005344-199503000-00025

M3 - Article

C2 - 7769821

AN - SCOPUS:0028968550

SN - 0160-2446

VL - 25

SP - 508

EP - 510

JO - Journal of Cardiovascular Pharmacology

JF - Journal of Cardiovascular Pharmacology

IS - 3

ER -

Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this