Abietic acid inhibits lipoxygenase activity

N. Nuray Ulusu; Dilek Ercil; M. Koray Sakar; E. Ferhan Tezcan

doi:10.1002/ptr.983

Abietic acid inhibits lipoxygenase activity

N. Nuray Ulusu
, Dilek Ercil
, M. Koray Sakar
, E. Ferhan Tezcan

Division of Pharmacognosy (Pharmacy)

Hacettepe University

Research output: Contribution to journal › Article › peer-review

66 Citations (Scopus)

Abstract

In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC₅₀ of 29.5 ± 1.29 νM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.

Original language	English
Pages (from-to)	88-90
Number of pages	3
Journal	Phytotherapy Research
Volume	16
Issue number	1
DOIs	https://doi.org/10.1002/ptr.983
Publication status	Published - 2002

Keywords

Abies nordmanniana ssp. bornmuelleriana
Abietic acid
Inhibition
Soybean 5-lipoxygenase

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title = "Abietic acid inhibits lipoxygenase activity",

abstract = "In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC50 of 29.5 ± 1.29 νM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.",

keywords = "Abies nordmanniana ssp. bornmuelleriana, Abietic acid, Inhibition, Soybean 5-lipoxygenase",

author = "\{Nuray Ulusu\}, N. and Dilek Ercil and \{Koray Sakar\}, M. and \{Ferhan Tezcan\}, E.",

year = "2002",

doi = "10.1002/ptr.983",

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journal = "Phytotherapy Research",

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T1 - Abietic acid inhibits lipoxygenase activity

AU - Nuray Ulusu, N.

AU - Ercil, Dilek

AU - Koray Sakar, M.

AU - Ferhan Tezcan, E.

PY - 2002

Y1 - 2002

N2 - In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC50 of 29.5 ± 1.29 νM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.

AB - In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5-lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC50 of 29.5 ± 1.29 νM was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions.

KW - Abies nordmanniana ssp. bornmuelleriana

KW - Abietic acid

KW - Inhibition

KW - Soybean 5-lipoxygenase

UR - https://www.scopus.com/pages/publications/0036158369

U2 - 10.1002/ptr.983

DO - 10.1002/ptr.983

M3 - Article

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AN - SCOPUS:0036158369

SN - 0951-418X

VL - 16

SP - 88

EP - 90

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 1

ER -

Abietic acid inhibits lipoxygenase activity

Abstract

Keywords

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