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A rare γ-pyranopyrazole skeleton: Design, one-pot synthesis and computational study

  • Muhammed Üçüncü
  • , Ceren Cantürk
  • , Erman Karakuş
  • , Hüseyin Zeybek
  • , Uǧur Bozkaya
  • , Emine Soydaş
  • , Ertan Şahin
  • , Mustafa Emrullahoǧlu
  • Izmir Institute of Technology
  • Ataturk University

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of γ-pyranopyrazole is furthermore fully supported by experimental and computational studies.

Original languageEnglish
Pages (from-to)7490-7494
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number31
DOIs
Publication statusPublished - 2016

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