A new perspective for biological activities of novel hexahydroquinoline derivatives

Cancer is a systemic disease that occurs by various molecular mechanisms and its certain treatment has not been achieved yet. Antimicrobial drugs are the only option for the treatment of infections cause by bacteria and fungi. However, most microorganisms might develop resistantance against these drugs. 1,4-Dihydropyridine (1,4-DHP) is a partially saturated form of pyridine ring which shows calcium channel modulator activity. In addition to this activity of 1,4-DHPs and analog compounds such as hexahydroquinoline (HHQ), other activities have also been investigated. In this study, two new HHQ derivatives were synthesized to obtain a lead compound which has anticancer and antimicrobial activity. The structures of the synthesized compounds were proved by spectral methods. These HHQ derivatives compounds were conjugated to magnetic nanoparticles to investigate the changes in their anticancer and antimicrobial activities. For this purpose, firstly, we synthesized silica-coated magnetic nanoparticles. The silica-coated magnetic nanoparticles were conjugated with HHQ to enhance anticancer and antimicrobial activities. Anticancer and antimicrobial activity studies were carried out for both compounds and magnetic nanoparticle (MNP) forms. In addition, the physicochemical and pharmacokinetic properties, lipophilicity, water solubility and druglikeness of the compounds were determined in silico. Altogether, our data indicate that the new hexahydroquinoline derivatives have anticancer activity and the magnetic nanoparticle form led to increasing to this activity.