Açik kalp cerrahisinde kardiyoplejiye eklenen esmolol veya glutamat-aspartatin miyokardiyal koruma üzerine Etkisi

Background: Esmolol has been found to prevent myocardial ischemia during cardiac surgery. Furthermore, adding glutamate-aspartate to blood cardioplegia was reported as myocardio-protcetive. We aimed to compare the myocardial protective effect of esmolol and glutamate-aspartat in blood cardioplegia in elective open heart surgery. Material and Methods: Forty five adult patients, ASA grade 3 scheduled for open heart surgery were included. Patients were randomly allocated according to the agent given in bolus added to cardioplegia by an anaesthetist who was blinded to the study; Group E (csmolol), Group GA (glutamate-aspartate), Group C (control). Cardiac output (CO), cardiac index (CI), troponin T (TT) and crcatinine kinase MB (CK) were recorded after induction (t₁), at the end of surgery (t₂) and at 24 h postoperatively (t₃). Results: Need of inotropic agent was more in Group C than the others. While values of CO in group C decreased , after the surgery values of CO was higher in Group E (p<0.05). Although there were no differences in CK among the groups in all times, after the surgery values of CK-t₃ and TT-t₃ increased in all patients. Values of TT-t₂ were higher in Group C than other groups during the operation. Conclusion: In open heart surgery, glutamate-aspartate and esmolol given in bolus added to blood cardioplegia are an advantage in myocardial protection.